
Chemical and Pharmaceutical Bulletin p. 280 - 283 (1996)
Update date:2022-08-04
Topics:
Takagi, Toshiyuki
Takahashi, Junko
Nakatsuka, Hirokazu
Koyama, Mayumi
Ando, Akira
Kumadaki, Itsumaro
We have reported an abnormal Grignard reaction of halothane (1) with carbonyl compounds (2). The reaction afforded 1-bromo-1-chloro-2,2,2- trifluoroethylcarbinols (3) as the major products at -53°C, while at 0°C, the main products were the dehalogenation
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