A method for synthesis of fluorine compounds using abnormal Grignard reaction of halothane. III. Simple synthesis of trifluoromethylchloroolefins

DOI: 10.1248/cpb.44.280

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Chemical and Pharmaceutical Bulletin p. 280 - 283 (1996)

Update date:2022-08-04

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Authors:

Takagi, Toshiyuki

Takahashi, Junko

Nakatsuka, Hirokazu

Koyama, Mayumi

Ando, Akira

Kumadaki, Itsumaro

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Article abstract of DOI:10.1248/cpb.44.280

We have reported an abnormal Grignard reaction of halothane (1) with carbonyl compounds (2). The reaction afforded 1-bromo-1-chloro-2,2,2- trifluoroethylcarbinols (3) as the major products at -53°C, while at 0°C, the main products were the dehalogenation

Full text of DOI:10.1248/cpb.44.280

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