Nickelalactone als Synthesebausteine: Sonochemische und Bimetallsktivierung der Kreuzkopplungsreaction mit Alkyl-halogeniden

Article abstract of DOI:10.1016/0022-328X(92)80077-B

Nickelalactones with five- and six-membered chelate ring structures can be synthesized in a simple one-pot reaction, starting from Ni(acac)2, bipy, Et3Al and cyclic anhydrides.In the presence of MnI2 and by activation with ultrasound they react selectively with alkyl iodides in cross coupling reactions.The reason for the activating effect of MnI2 is the formation of bimetallic complexes.Many reactive functional groups (e.g.COOR, CHO, CN) can be tolerated.Therefore the cross coupling reaction is of preparative value in the synthesis of functionalized carboxylic acids.