Preparation of 5-alkyl-3-carboxymethylrhodanines and their aldose reductase inhibitory activity

DOI: 10.1248/cpb.40.907

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 907 - 911 (1992)

Update date:2022-09-26

Topics:

Authors:

Ohishi Ohishi

Mukai Mukai

Nagahara

Yajima Yajima

Kajikawa

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Article abstract of DOI:10.1248/cpb.40.907

5-Alkyl-3-carboxymethylrhodanines (2) were prepared from 5-alkylmethylidene-3-carboxymethylrhodanines (1). The exo double bond of 1 was successfully reduced with NaBH₄. The 1,4-addition reaction path was confirmed on the basis of proton nuclear

Full text of DOI:10.1248/cpb.40.907

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