STEREOSELECTIVE SYNTHESIS OF THE HYDROXYETHYLENE ISOSTERE OF THE HIV PROTEASE (TYR-PRO) CLEAVAGE SITE

DOI: 10.1016/S0040-4039(00)79571-2

Source and publish data:

Tetrahedron Letters p. 2957 - 2960 (1992)

Update date:2022-08-03

Topics:

Authors:

Thompson, Wayne J.

Ball, Richard G.

Darke, Paul L.

Zugay, Joan A.

Thies, J. E.

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Article abstract of DOI:10.1016/S0040-4039(00)79571-2

The stereoselective syntheses and IC₅₀'s of Tyr-HE-Pro based inhibitors are reported.The <2S,3S,4S,5S>-stereochemistry was preferred by HIV-1 protease.

Full text of DOI:10.1016/S0040-4039(00)79571-2

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