STEREOSELECTIVE SYNTHESIS OF THE HYDROXYETHYLENE ISOSTERE OF THE HIV PROTEASE (TYR-PRO) CLEAVAGE SITE

DOI: 10.1016/S0040-4039(00)79571-2

Source and publish data:

Tetrahedron Letters p. 2957 - 2960 (1992)

Update date:2022-08-03

Topics:

Authors:

Thompson, Wayne J.

Ball, Richard G.

Darke, Paul L.

Zugay, Joan A.

Thies, J. E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)79571-2

The stereoselective syntheses and IC₅₀'s of Tyr-HE-Pro based inhibitors are reported.The <2S,3S,4S,5S>-stereochemistry was preferred by HIV-1 protease.

Full text of DOI:10.1016/S0040-4039(00)79571-2

Products guided by the article

Product name:(4S,5R)-4-(4-Benzyloxy-benzyl)-5-((1S,2R)-2-hydroxymethyl-cyclopentyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Cas No:142696-07-9

R&D Labs maybe for 142696-07-9

Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD

website:http://www.xypharm.com/

Contact:+86-515-84383317

Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Shao Xing Empire Import&Export CO.,ltd

Contact:86-575-82127757

Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China

Relevant to this article

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors

Doi:10.1016/j.bmcl.2013.01.121
(2013)
A New, Versatile and Stereospecific Route to Unusual Amino Acids: The Enantiospecific Total Synthesis of Statine Amide and Its Three Stereoisomers

Doi:10.1021/jo00042a026
(1992)
An unusual half-open cubane-like tetranuclear copper(II) complex supported by both μ-alkoxo and μ₃-hydroxo bridges: Structure, magnetic properties, EPR and DFT studies

Doi:10.1016/j.poly.2013.01.044
(2013)
Synthesis of novel fused 4,5-dihydro-1,2,3-triazolo[1,5-a][1,4] benzodiazepine derivatives via four-component Ugi-Smiles-type reaction

Doi:10.1016/j.tet.2013.02.023
(2013)
The marriage of metallacycle transfer chemistry with suzuki-miyaura cross-coupling to give main group element-containing conjugated polymers

Doi:10.1021/ja402242z
(2013)
Novel planar and star-shaped molecules: Synthesis, electrochemical and photophysical properties

Doi:10.1016/j.saa.2013.01.047
(2013)

Article Doi