Tetrahedron p. 4593 - 4600 (1992)
Update date:2022-08-06
Topics: Naphthalene Lithiation Allylic Benzylic Catalysed Allyl Benzyl Mesylates
Guijarro, D.
Mancheno, B.
Yus, M.
The reaction of allylic or benzylic mesylates (1) with an excess of lithium powder and a catalytic amount of naphthalene (4 mol percent) in THF at -78 deg C leads to a solution of the corresponding organolithium derivatives, which by treatment with different electrophiles yield the expected products 2-7.As an alternative route, the process can be carried out at 0 deg C by adding the corresponding mesylate together with the electrophile to a suspension of the activated lithium in THF, in a Barbier-type reaction.
View MoreGuangzhou PI & PI Biotech Inc. Ltd.
Contact:+86-20-81716320
Address:Suite 501,198 Kaiyuan Ave.,Science City, Guangzhou,China
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.
Contact:+86-750-2881198
Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Guangzhou PI & PI Biotech Inc. Ltd.
Contact:+86-20-81716320
Address:Suite 501,198 Kaiyuan Ave.,Science City, Guangzhou,China
Shanghai Haoyuan Chemexpress Co., Ltd.
website:https://www.chemexpress.com/
Contact:86-21-58950125
Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Doi:10.1021/ol400692b
(2013)Doi:10.1016/S0040-4039(00)92082-3
(1992)Doi:10.1002/ardp.19923250610
(1992)Doi:10.1016/j.catcom.2013.01.014
(2013)Doi:10.1021/acs.orglett.7b00344
(2017)Doi:10.1021/jp9116134
(2010)