Journal of Medicinal Chemistry p. 3567 - 3572 (1992)
Update date:2022-08-03
Topics:
Comber, Robert N.
Reynolds, Robert C.
Friedrich, Joyce D.
Manguikian, Roupen A.
Buckheit, Robert W.
et al.
A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone.When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μM
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