
Heterocycles p. 381 - 388 (2013)
Update date:2022-08-04
Topics:
Tayama, Eiji
Sato, Ryota
Ito, Motoshi
Iwamoto, Hajime
Hasegawa, Eietsu
A unique and simple preparative method for N-cyano-a-aryl-pipecolinic acid esters via base-induced Sommelet-Hauser rearrangement, the von Braun reaction, and intramolecular a-alkylation is reported. The removal of the N-cyano substituent was achieved by hydrogenation and hydride reduction.
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Doi:10.1016/j.ica.2012.12.040
(2013)Doi:10.1002/ejoc.201201506
(2013)Doi:10.1021/acsmedchemlett.6b00119
(2016)Doi:10.1021/ol4008876
(2013)Doi:10.1016/j.tetlet.2013.08.083
(2013)Doi:10.1021/jo00055a019
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