A unique and simple preparative method for α-aryl-pipecolinic acid esters via base-induced sommelet-hauser rearrangement

DOI: 10.3987/COM-12-12619

Source and publish data:

Heterocycles p. 381 - 388 (2013)

Update date:2022-08-04

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Authors:

Tayama, Eiji

Sato, Ryota

Ito, Motoshi

Iwamoto, Hajime

Hasegawa, Eietsu

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Article abstract of DOI:10.3987/COM-12-12619

A unique and simple preparative method for N-cyano-a-aryl-pipecolinic acid esters via base-induced Sommelet-Hauser rearrangement, the von Braun reaction, and intramolecular a-alkylation is reported. The removal of the N-cyano substituent was achieved by hydrogenation and hydride reduction.

Full text of DOI:10.3987/COM-12-12619

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