Synthesis of 21-aryl and heteroaryl ethisterones and the corresponding A-ring substituted [2,3-d]isoxazoles

Article abstract of DOI:10.1055/s-1992-26151

Palladium(0) catalyzed coupling reaction of ethisterone [6; (17α)-17-hydroxypregn-4-en-20-yn-3-one] with aromatic/heteroaromatic halides gave C-21 substituted derivatives 7. Hydroxymethylation of the latter compounds followed by treatment with hydroxylami