Generation and Intramolecular Cycloaddition of o-Quinonemethides in Protic Solvent. An Efficient Synthesis of (-)-trans-Hexahydrocannabinol

Article abstract of DOI:10.1246/cl.1992.1237

A very facile and efficient synthesis of (-)-trans-hexahydrocannabinol was achieved through the intramolecular Diels-Alder reaction of an o-quinonemethide derived from 2-(1-hydroxycitronellyl)olivetol 1,3-bismethoxymethyl ether in methanol.