Substrate-related phosphonopeptides, a new class of thrombin inhibitors

DOI: 10.1016/0040-4039(91)80512-5

Source and publish data:

Tetrahedron Letters p. 7333 - 7336 (1991)

Update date:2022-08-04

Topics:

Authors:

Cheng Cheng

Goodwin Goodwin

Scully Scully

Kakkar Kakkar

Claeson Claeson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(91)80512-5

Novel phosphorus-containing peptidomimetics, D-Aa-Pro-Aa(P)(OPh)₂, with lipophilic amino acids at the P₃ positions and amino phosphonic acids with neutral side chains in the P₁ position have been designed and synthesized as thrombin inhibitors.

Full text of DOI:10.1016/0040-4039(91)80512-5

Products guided by the article

Product name:Z-D-Dpa-Pro-NHPGly^P(OPh)2

Cas No:143729-52-6

R&D Labs maybe for 143729-52-6

SPE Chemicals Co.,Ltd

Contact:

Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
wuxi huabin bio-tech Co.,Ltd(expird)

Contact:86-0510-85133006

Address:hubin road NO157
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Shanghai PotentPharm Science and Technology Co.,Ltd

Contact:86-021-51969655

Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Shangyu Sanhechemicals Co.,LTD.

Contact:86-0571-56696839

Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China

Relevant to this article

Organocatalyzed direct asymmetric aldol reaction of isatins in water: Low catalyst loading in command

Doi:10.1016/j.tet.2013.04.044
(2013)
Group IV organometallic compounds based on dianionic "pincer" ligands: Synthesis, characterization, and catalytic activity in intramolecular hydroamination reactions

Doi:10.1002/chem.201203644
(2013)
Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide

Doi:10.1021/ja508846g
(2014)
Palladium-catalyzed highly regio- and stereoselective carbon-carbon bond formation reaction of γ-substituted vinylaziridines with a silylated masked acyl cyanide reagent

Doi:10.1016/j.tet.2013.04.129
(2013)
Imidazo[1,2-a]pyridines. III. Synthesis and bradycardic activity of new 5-imidazo[1,2-a]pyridin-6-ylpyridine derivatives

Doi:10.1248/cpb.40.1486
(1992)
Enantioselective Michael addition/iminium ion cyclization cascades of tryptamine-derived ureas

Doi:10.1021/ol401039h
(2013)

Article Doi