A Convenient Synthesis of Platelet-Activating Factors and Their Analogues from Chiral Epichlorohydrin

Article abstract of DOI:10.1246/cl.1992.1417

Two platelet activating factors (PAF) were conveniently prepared from optically active epichlorohydrin via 5 steps in 15-16percent total yield.Four analogues containing oleoyl, propyl, p-trifluoromethylphenoxy, and N,N-dimethyldithiocarbamoyl groups were also prepared.