Nucleophilic substitution at the acetalic center of mandelate 1,3-dioxolan-4-ones using magnesio-copper reagents: Application to the synthesis of chiral secondary alcohols

Article abstract of DOI:10.1016/S0040-4039(00)79132-5

Ethereal magnesio-copper reagents, in contrast to lithio-copper reagents, add stereoselectively to mandelic acid derived 1,3-dioxolan-4-ones to afford optically active secondary alcohols after removal of the chiral auxiliary.