Nickel-catalyzed cross-coupling reaction of acetylenic sulfones with alkynyl Grignard reagents: A facile method for the preparation of unsymmetrical 1,3-diynes

Article abstract of DOI:10.1016/j.tetlet.2013.05.049

The cross-coupling reaction of acetylenic sulfones with acetylenic Grignard reagents was realized by using Ni(acac)₂ as catalyst to afford unsymmetrical 1,3-diynes under mild conditions without homocoupling byproducts. By using this method, 1,4-diaryl-1,3-diynes could be obtained in moderate to good yields (59-83%), whereas, the yields for alkyl substituted 1,3-diynes are lower (30-54%).