Cleavage of tert-butyldimethylsilyl ethers by chloride ion

DOI: 10.1016/S0040-4039(97)10479-8

Source and publish data:

Tetrahedron Letters p. 327 - 330 (1998)

Update date:2022-08-05

Topics: Cleavage Experimental terms tert-butyldimethylsilyl ethers

Authors:

Farras, Jaume

Serra, Carme

Vilarrasa, Jaume

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Article abstract of DOI:10.1016/S0040-4039(97)10479-8

A general method for the selective cleavage of tert-butyldimethylsilyl ethers in the presence of tert-butyldiphenylsilyl ones has been established using a combination of H₂O and a concentrated solution of LiCl in DMF at 90°C. Since no acids, bases, reducing or oxidizing agents are used, the method seems to be very appropiate for the deprotection of TBDMS ethers in the presence of other sensitive functional groups.

Full text of DOI:10.1016/S0040-4039(97)10479-8

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