Stereoselective total synthesis of (+)-lactacystin from D-glucose

Article abstract of DOI:10.1016/S0040-4020(97)01015-6

The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor having an α,α-disubstituted α- amino acid structure, is described. The highly functionalized γ- lactam portion possessing a tetra-substituted carbon w