Facile enzymatic preparation for enantiomeric β-lactams

DOI: 10.1248/cpb.40.2227

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2227 - 2229 (1992)

Update date:2022-08-02

Topics: Facile β-Lactams Experimental terms Enantiomeric Enzymatic preparation

Authors:

Nagai Nagai

Shiozawa

Achiwa Achiwa

Terao Terao

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Article abstract of DOI:10.1248/cpb.40.2227

Optically active β-lactams were obtained conveniently by lipase-catalyzed enantioselective hydrolysis of 1-acyloxymethyl-2-azetidinones and esterification of 1-hydroxymethyl-3,3-dimethyl-2-azetidinone with vinyl acetate in organic solvent.

Full text of DOI:10.1248/cpb.40.2227

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Product name:(S)-(+)-2-hydroxymethyl-3,3-dimethyl-4-phenyl-2-azetidinone

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