Chemical and Pharmaceutical Bulletin p. 2491 - 2496 (1983)
Update date:2022-08-04
Topics:
Itokawa
Aiyama
Ikuta
With the aim of correlating pungency with substituent groups on one benzene ring, various analogues of yakuchinones were synthesized by means of the Claisen-Schmidt reaction. Their pungencies were assessed by direct comparison of the threshold concentrations obtained in taste experiments. The presence of a phenolic hydroxyl group was indispensable for high pungency, while that of a 1,2-double bond of the heptanone part tended to decrease the pungency.
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Doi:10.1021/ja00977a027
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(1993)Doi:10.1021/jm00057a008
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(2013)Doi:10.1002/hlca.19930760120
(1993)Doi:10.1080/15257779408009483
(1994)
