Synthesis of diarylheptanoids and assessment of their pungency

DOI: 10.1248/cpb.31.2491

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2491 - 2496 (1983)

Update date:2022-08-04

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Authors:

Itokawa Itokawa

Aiyama Aiyama

Ikuta Ikuta

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Article abstract of DOI:10.1248/cpb.31.2491

With the aim of correlating pungency with substituent groups on one benzene ring, various analogues of yakuchinones were synthesized by means of the Claisen-Schmidt reaction. Their pungencies were assessed by direct comparison of the threshold concentrations obtained in taste experiments. The presence of a phenolic hydroxyl group was indispensable for high pungency, while that of a 1,2-double bond of the heptanone part tended to decrease the pungency.

Full text of DOI:10.1248/cpb.31.2491

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