Synthesis p. 51 - 53 (1993)
Update date:2022-07-29
Topics:
Quallich
Morrissey
A general synthesis of indol-2(3H)-ones (oxindoles), was developed based on the addition of dimethyl malonate to commercially available halonitrobenzenes. The advantage of this route over many other oxindole syntheses was the regiochemical control of the substitution pattern on the aromatic ring.
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