Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6- methylpyridin-2(1H)-one and analogues

DOI: 10.1021/jm00060a002

Source and publish data:

Journal of Medicinal Chemistry p. 953 - 966 (1993)

Update date:2022-08-04

Topics:

Authors:

Hoffman Hoffman

Smith Smith

Rooney Rooney

Fisher Fisher

Wai Wai

Thomas Thomas

Bamberger

Barnes Barnes

Williams

Jones Jones

Olson Olson

O'Brien O'Brien

Goldman Goldman

Nunberg Nunberg

Quintero

Schleif Schleif

Emini Emini

Anderson

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Article abstract of DOI:10.1021/jm00060a002

A new series of potent specific 2-pyridinone reverse transcriptase (RT) inhibitors was developed based on the preliminary development lead 3- [(phthalimido)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (3), a non-nucleoside derivative which exhibited weak anti

Full text of DOI:10.1021/jm00060a002

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Product name:2-(benzyloxy)-5-(dimethylamino)-6-methylnicotinonitrile

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