Bioorganic and Medicinal Chemistry Letters p. 1443 - 1448 (1996)
Update date:2022-08-04
Topics: Optimization Structure-Activity Relationship (SAR) Analysis Literature Review Synthesis of Compounds Publication and Patents Toxicity and ADME Profiling Animal Models (if required) Scale-Up and Further Development
Tanaka, Akito
Sakai, Hiroyoshi
Ishikawa, Takatoshi
Nakanishi, Isao
Ohkubo, Mitsuru
Aoki, Toshiaki
Motoyama, Yukio
Takasugi, Hisashi
Low molecular weight inhibitors of platelet aggregation are described. Compounds studied in this work were derived from the presumed active conformation of the adhesion tripeptide, ArgGlyAsp, using computer simulations. These studies led to the synthesis of a potent anti-platelet agent, 4-(4-amidinophenoxy)-butanoylaspartylvaline (6, FK633).
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