Bioorganic and Medicinal Chemistry Letters p. 1519 - 1524 (1997)
Update date:2022-09-26
Topics:
Kohno, Yasushi
Awano, Katsuya
Miyashita, Mitsutomo
Ishizaki, Takayoshi
Kuriyama, Kazuhiko
Sakoe, Yasuhiko
Kudoh, Shinji
Saito, Koji
Kojima, Eisuke
A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. (S)-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6- quinolineacetic acid (IRA-378) exhibits the effect against both acute and chronic inflammations. It also has suppressive effects of bone destruction in adjuvant arthritis and Ca release from bones in vitro.
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