Synthesis and antirheumatic activity of novel tetrahydro-6-quinolineacetic acid derivatives

DOI: 10.1016/S0960-894X(97)00262-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1519 - 1524 (1997)

Update date:2022-09-26

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Authors:

Kohno, Yasushi

Awano, Katsuya

Miyashita, Mitsutomo

Ishizaki, Takayoshi

Kuriyama, Kazuhiko

Sakoe, Yasuhiko

Kudoh, Shinji

Saito, Koji

Kojima, Eisuke

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Article abstract of DOI:10.1016/S0960-894X(97)00262-X

A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. (S)-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6- quinolineacetic acid (IRA-378) exhibits the effect against both acute and chronic inflammations. It also has suppressive effects of bone destruction in adjuvant arthritis and Ca release from bones in vitro.

Full text of DOI:10.1016/S0960-894X(97)00262-X

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Product name:methyl 8-chloro-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoline-6-acetate

Cas No:149264-77-7

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