Thiazolo[5,4-b]acridines and thiazolo[4,5-b]acridines: Probable pharmacophores of antiviral and anti-tumor marine alkaloids

Article abstract of DOI:10.1016/S0040-4039(00)71212-3

Structural simplification of pentacyclic and hexacyclic antiviral and anti-tumor acridine alkaloids such as dercitin, cyclodercitin and kuanoniamine led to the identification of the thiazo[5,4-b]acridine or the isomeric thiazolo[4,5-b]acridine nucleus as