An efficient asymmetric synthesis of the four stereoisomers of 3-hydroxyleucine

DOI: 10.1016/0040-4039(93)88055-N

Source and publish data:

Tetrahedron Letters p. 4447 - 4448 (1993)

Update date:2022-08-02

Topics:

Authors:

Sunazuka, Toshiaki

Nagamitsu, Tohru

Tanaka, Haruo

Omura, Satoshi

Sprengeler, Paul A.

Smith III, Amos B.

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Article abstract of DOI:10.1016/0040-4039(93)88055-N

The four stereoisomers of 3-hydroxyleucine have been prepared in high overall yield and enantiomeric purity. Key steps include Sharpless asymmetric epoxidation, benzyl isocyanate-induced epoxide opening, and epimerization of an intermediate oxazolidinone ester.

Full text of DOI:10.1016/0040-4039(93)88055-N

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