Effect of fluorination on the pharmacological profile of 11β isomers of fulvestrant in breast carcinoma cells

DOI: 10.1021/jm801154q

Source and publish data:

Journal of Medicinal Chemistry p. 883 - 887 (2009)

Update date:2022-07-29

Topics:

Authors:

Agouridas, Vangelis

Magnier, Emmanuel

Blazejewski, Jean-Claude

La?os, Ioanna

Cleeren, Anny

Nonclercq, Denis

Laurent, Guy

Leclercq, Guy

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Article abstract of DOI:10.1021/jm801154q

We describe the synthesis of an 11/β isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11β side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4

Full text of DOI:10.1021/jm801154q

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