Urethane protected derivatives of 1-guanylpyrazole for the mild and efficient preparation of guanidines

Article abstract of DOI:10.1016/S0040-4039(00)79163-5

Bis-urethane protected derivatives of 1-guanylpyrazole were prepared and found to readily react with relatively amines at room temperature to produce bis-protected guanidines in good yields. Simultaneous removal of both protecting groups from these products efficiently produced monosubstituted guanadines.