PROTEASE-CATALYZED ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINES

DOI: 10.1016/S0040-4039(00)79178-7

Source and publish data:

Tetrahedron Letters p. 3441 - 3444 (1993)

Update date:2022-08-05

Topics:

Authors:

Hirose, Yoshihiko

Kariya, Kinya

Sasaki, Ikuharu

Kurono, Yoshiaki

Achiwa, Kazuo

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Article abstract of DOI:10.1016/S0040-4039(00)79178-7

The first enantioselective protease-catalyzed hydrolyses of 1,4-dihydropyridine-3,5-dicarboxylic diesters were developed.The monoesters obtained had high optical purity and were useful building blocks which could easily lead to optically active Ca-blockers.

Full text of DOI:10.1016/S0040-4039(00)79178-7

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