Total Synthesis of (-)-Quinocarcin and (-)-10-Decarboxyquinocarcin

DOI: 10.1016/S0040-4039(00)73850-0

Source and publish data:

Tetrahedron Letters p. 5747 - 5750 (1993)

Update date:2022-09-26

Topics:

Authors:

Katoh, Tadashi

Kirihara, Masayuki

Nagata, Yuriko

Kobayashi, Yuko

Arai, Katsuko

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)73850-0

The title total synthesis was accomplished by employing diastereoselective reduction of 1,3-disubstituted isoquinolines as a key step.The cytotoxicity of 10-decarboxyquinocarcin and its 7-cyano congeners were found to be 10-1000 times more potent than tho

Full text of DOI:10.1016/S0040-4039(00)73850-0

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