Tetrahedron Letters p. 7133 - 7136 (1993)
Update date:2022-08-04
Topics:
Ramage, Robert
Wahl, Franck Olivier
A new highly hydrophobic 5'-hydroxyl protecting group (Tbf-DMTr) has been designed for the purification of synthetic oligonucleotides.Tbf-DMTr-oligonucleotides are strongly retained on RP-HPLC allowing a facile separation from truncated sequences.Subsequently the group can be removed in acidic conditions.The ultra-violet properties of Tbf-DMTr enable easy detection.The synthesis and purification of long oligonucleotides ( >100 mer) is envisaged.Keywords: RP-HPLC; 4-(17-Tetrabenzo
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Doi:10.1016/S0957-4166(00)80056-7
(1993)Doi:10.1021/jo01017a048
(1965)Doi:10.1021/jo00828a009
(1970)Doi:10.1016/j.bioorg.2004.05.001
(2004)Doi:10.1016/j.ejmech.2008.04.004
(2009)Doi:10.1039/c3ob41722k
(2014)
