Tetrahedron Letters p. 7133 - 7136 (1993)
Update date:2022-08-04
Topics:
Ramage, Robert
Wahl, Franck Olivier
A new highly hydrophobic 5'-hydroxyl protecting group (Tbf-DMTr) has been designed for the purification of synthetic oligonucleotides.Tbf-DMTr-oligonucleotides are strongly retained on RP-HPLC allowing a facile separation from truncated sequences.Subsequently the group can be removed in acidic conditions.The ultra-violet properties of Tbf-DMTr enable easy detection.The synthesis and purification of long oligonucleotides ( >100 mer) is envisaged.Keywords: RP-HPLC; 4-(17-Tetrabenzo
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