Tetrahedron Letters p. 7133 - 7136 (1993)
Update date:2022-08-04
Topics:
Ramage, Robert
Wahl, Franck Olivier
A new highly hydrophobic 5'-hydroxyl protecting group (Tbf-DMTr) has been designed for the purification of synthetic oligonucleotides.Tbf-DMTr-oligonucleotides are strongly retained on RP-HPLC allowing a facile separation from truncated sequences.Subsequently the group can be removed in acidic conditions.The ultra-violet properties of Tbf-DMTr enable easy detection.The synthesis and purification of long oligonucleotides ( >100 mer) is envisaged.Keywords: RP-HPLC; 4-(17-Tetrabenzo
Ningbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
Neworld Chemical Co., Ltd Shanghai(expird)
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Contact:+86-838-5655598
Address:Guanghan Nanfeng Industrial Zone
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Wuhan Sunrise Pharmaceutical Technology Co., Ltd
Contact:+86-27-83314682
Address:Room 340, New material Industrial base No.17, Gu Tian Five Lu , Qiaokou District, Wuhan , China
Doi:10.1016/S0957-4166(00)80056-7
(1993)Doi:10.1021/jo01017a048
(1965)Doi:10.1021/jo00828a009
(1970)Doi:10.1016/j.bioorg.2004.05.001
(2004)Doi:10.1016/j.ejmech.2008.04.004
(2009)Doi:10.1039/c3ob41722k
(2014)
