Facile synthesis and reactions of (Z)-α,β-didehydroamino aldehydes from (Z)-α,β-didehydroamino acid esters

Article abstract of DOI:10.1055/s-1993-26020

The general synthesis of (Z)-α,β-didehydroamino aldehydes 3 was accomplished by the reduction of (Z)-α,β-didehydroamino acid esters with lithium aluminum hydride followed by Swern oxidation. Subsequent Grignard reaction of 3 with alkylmagnesium halides wa