Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 11. 3-Hydroxycyprodime and Analogues: Opioid Antagonist Profile in Comparison to Cyprodime

DOI: 10.1021/jm00016a010

Source and publish data:

Journal of Medicinal Chemistry p. 3071 - 3077 (1995)

Update date:2022-08-05

Topics:

Authors:

Schmidhammer, Helmut

Jennewein, Herwig K.

Krassnig, Roland

Traynor, John R.

Patel, Dinesh

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00016a010

A series of 3-hydroxy-substituted analogues (3-7) of the μ selective opioid antagonist cyprodime has been synthesized in order to evaluate the role of a hydroxy group at C-3 concerning μ opioid antagonist selectivity.Compounds 3-7 were tested in bioassays

Full text of DOI:10.1021/jm00016a010

Products guided by the article

Product name:3-hydroxycyprodime

Cas No:154711-64-5

R&D Labs maybe for 154711-64-5

GUANGZHOU MEDCAN PHARMATECH LTD

website:http://www.gzmedcan.com

Contact:+86-20-82519649

Address:Building J,Room 101,1 JiangtashanRd,Guang Zhou Science City,Guang Zhou ,China
guide(suzhou) fine materials co. ltd

Contact:0512-80972173

Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD

Contact:+86-570-6040289

Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Jinhua Haoyuan Chemical CO., LTD(expird)

Contact:86-579-82465583

Address:Jinhua,Zhejiang
Tradlon Chemical Co., Ltd.

Contact:+86-710-3516804

Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei

Relevant to this article

Catalytic ugi-type condensation of α-isocyanoacetamide and chiral cyclic imine: Access to asymmetric construction of several heterocycles

Doi:10.1021/jo4000702
(2013)
Studies on novel synthetic methodologies, part XII: An efficient one-pot access to 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-phenylisoindolo[2,1-a]quinazolin-11(6a H)-ones

Doi:10.1055/s-0032-1317761
(2013)
Quantitative evaluation of the stability of gem -diaurated species in reactions with nucleophiles

Doi:10.1021/om400083f
(2013)
On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans

Doi:10.1016/j.bmcl.2012.10.079
(2013)
Polyoxometalate immobilized on MOF-5 as an environment-friendly catalyst for the synthesis of poly-functionalized 3-pyrrolin-2-ones

Doi:10.1002/aoc.6064
(2021)
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives1

Doi:10.1134/S1068162012030028
(2012)

Article Doi