Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 11. 3-Hydroxycyprodime and Analogues: Opioid Antagonist Profile in Comparison to Cyprodime

DOI: 10.1021/jm00016a010

Source and publish data:

Journal of Medicinal Chemistry p. 3071 - 3077 (1995)

Update date:2022-08-05

Topics:

Authors:

Schmidhammer, Helmut

Jennewein, Herwig K.

Krassnig, Roland

Traynor, John R.

Patel, Dinesh

et al. et al.

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Article abstract of DOI:10.1021/jm00016a010

A series of 3-hydroxy-substituted analogues (3-7) of the μ selective opioid antagonist cyprodime has been synthesized in order to evaluate the role of a hydroxy group at C-3 concerning μ opioid antagonist selectivity.Compounds 3-7 were tested in bioassays

Full text of DOI:10.1021/jm00016a010

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