Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 11. 3-Hydroxycyprodime and Analogues: Opioid Antagonist Profile in Comparison to Cyprodime

DOI: 10.1021/jm00016a010

Source and publish data:

Journal of Medicinal Chemistry p. 3071 - 3077 (1995)

Update date:2022-08-05

Topics:

Authors:

Schmidhammer, Helmut

Jennewein, Herwig K.

Krassnig, Roland

Traynor, John R.

Patel, Dinesh

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00016a010

A series of 3-hydroxy-substituted analogues (3-7) of the μ selective opioid antagonist cyprodime has been synthesized in order to evaluate the role of a hydroxy group at C-3 concerning μ opioid antagonist selectivity.Compounds 3-7 were tested in bioassays

Full text of DOI:10.1021/jm00016a010

Products guided by the article

Product name:3-hydroxycyprodime

Cas No:154711-64-5

R&D Labs maybe for 154711-64-5

Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
ChengduChroma-BiotechCo.,Ltd.

Contact:86-28-61993785

Address:No.70-13-21, North Section, Erhuan
Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
Xi'an Costrong Pharmaceutical Co., Ltd.

Contact:029- 68576496

Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian

Relevant to this article

Catalytic ugi-type condensation of α-isocyanoacetamide and chiral cyclic imine: Access to asymmetric construction of several heterocycles

Doi:10.1021/jo4000702
(2013)
Studies on novel synthetic methodologies, part XII: An efficient one-pot access to 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-phenylisoindolo[2,1-a]quinazolin-11(6a H)-ones

Doi:10.1055/s-0032-1317761
(2013)
Quantitative evaluation of the stability of gem -diaurated species in reactions with nucleophiles

Doi:10.1021/om400083f
(2013)
On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans

Doi:10.1016/j.bmcl.2012.10.079
(2013)
Polyoxometalate immobilized on MOF-5 as an environment-friendly catalyst for the synthesis of poly-functionalized 3-pyrrolin-2-ones

Doi:10.1002/aoc.6064
(2021)
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives1

Doi:10.1134/S1068162012030028
(2012)

Article Doi