Chemistry of Heterocyclic Compounds p. 945 - 948 (1993)
Update date:2022-08-05
Topics: Synthesis Compound Experimental Antiviral agent
Ozerov, A. A.
Brel', A. K.
A convenient method has been developed for the synthesis of 9-allyloxymethylguanine. The direct alkylation of the trimethylsilyl derivative of guanine allyloxymethyl chloride gives a 64 percent yield of 9- and 7-allyloxymethylguanine (3:1). A mixture of 9- and 7-allyloxymethyl-N-acetylguanine (7:4) can be obtained in 56 percent yield by the condensation of diacetylguanine with allyloxymethyl acetate in dimethyl sulfoxide in the presences of p-toluenesulfonic acid.
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