The [2,3] Wittig rearrangement: Studies toward the synthesis of the bicylic core structure of the enediyne antibiotics

Article abstract of DOI:10.1016/S0040-4039(00)61313-8

The dihydro compound 14 related to the bicyclic core structure of dynemicin and calicheamicin/esperamicin was obtained by a [2,3] Wittig ring contraction of the cyclic ether 13. Similar attempts with 4 gave the 12-membered carbocycle 6 resulting from a [1