New γ-thiazolidine-1,3-dithiolanes as radioprotectors

DOI: 10.1016/0223-5234(94)90208-9

Source and publish data:

European Journal of Medicinal Chemistry p. 121 - 126 (1994)

Update date:2022-07-30

Topics:

Authors:

Law, Ho.

Pera, M. H.

Taillandier, G.

Fatome, M.

Laval, J. D.

Leclerc, G.

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Article abstract of DOI:10.1016/0223-5234(94)90208-9

Fourteen γ-thiazolidine-1,3-dithiolanes were prepared and tested as radioprotective agents.The combination within a single molecule of thiazolidine and dithiolane moieties, both of which are known for their radioprotective properties, was achieved for the first time.Several molecules show significant radioprotective activity: immediate 4l; delayed 4b, 4f, 4h; or immediate and prolonged 4a. dithiolanes / thiazolidines / radioprotectors / LD50 30 days

Full text of DOI:10.1016/0223-5234(94)90208-9

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