Novel small renin inhibitors containing 4,5- or 3,5-Dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites

Article abstract of DOI:10.1016/S0968-0896(98)80011-4

Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P₂-P₃ sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesi