New antiviral antibiotics, kistamicins A and B. II. Structure determination

Article abstract of DOI:10.7164/antibiotics.46.1812

The structures of antiviral antibiotics kistamicins A and B have been determined by a combination of chemical degradation and spectral analysis. They are commonly composed of D-tyrosine 3,5-dihydrophenylglycine a biphenyl ether bis-amino acid and a diphenyl substituted indole tris-amino acid forming a tricyclic ring structure. Kistamicin B possessed a phenethylamide at the amino terminal of kistamicin A. They are structurally related to the nuclei of the vancomycin group antibiotics particularly to antibiotic complestatin.