Helvetica Chimica Acta p. 111 - 120 (1994)
Update date:2022-08-02
Topics:
Martin
Winkler
We describe here the synthesis of the title compounds 3-5, starting from highly substituted aminoindoles. The annelated pyridine rings were built up in each case with dimethyl 4-oxoglutaconate according to Corey's procedure. All three o-quinone derivatives 3-5 are stable compounds, comparable to PQQ-triester. The azaisomers vary in biological activity from practically inactive to strong inhibition of the α-amidating enzyme or the ornithin decarboxylase.
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Doi:10.1007/BF02219410
(1994)Doi:10.1016/S0040-4039(00)73250-3
(1994)Doi:10.1016/0022-328X(93)83392-9
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(2003)