Tetrahedron p. 5361 - 5368 (1994)
Update date:2022-07-29
Topics:
Parmentier, Gilles
Schmitt, Gaby
Dolle, Frederic
Luu, Bang
A convergent synthesis of 2′-O-methyl uridine (1) is described. The key steps in our synthesis are: (1) a facile obtention of the 2′-O-methyl sugar synthon using totally selective and efficient methylation conditions; (2) a stereoselective high-yield condensation with an uracil derivative, yielding the desired β-form.
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