A convergent synthesis of 2′-o-methyl uridine

Article abstract of DOI:10.1016/S0040-4020(01)80693-1

A convergent synthesis of 2′-O-methyl uridine (1) is described. The key steps in our synthesis are: (1) a facile obtention of the 2′-O-methyl sugar synthon using totally selective and efficient methylation conditions; (2) a stereoselective high-yield condensation with an uracil derivative, yielding the desired β-form.