Asymmetric Synthesis of the Volatile Anesthetic 1,2,2,2-Tetrafluoroethyl Chlorofluoromethyl Ether Using a Stereospecific Decarboxylation of Unusual Stereochemical Outcome

DOI: 10.1021/jo00110a041

Source and publish data:

Journal of Organic Chemistry p. 1319 - 1325 (1995)

Update date:2022-07-29

Topics:

Authors:

Rozov, Leonid A.

Rafalko, Patrice W.

Evans, Suzanne M.

Brockunier, Linda

Ramig, Keith

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Article abstract of DOI:10.1021/jo00110a041

Acid 1 is optically resolved by diastereomeric amide formation/chromatography/hydrolysis.Decarboxylaion of the enantiomers of acid 1 gives the enantiomers of ether 2 with a very high degree of stereospecificity.The absolute configurations of both the star

Full text of DOI:10.1021/jo00110a041

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