On the Asymmetric Dihydroxylation of (2S,3R) 5-Phenylpent-4-en-2,3-diol Derivatives

Article abstract of DOI:10.1016/S0040-4020(01)90413-2

Sharpless OsO4 asymmetric dihydroxylation of derivatives of the unsaturated (2S,3R) diols 2 affords products 7a,b and 10 and the diastereoisomers 8a,b and 11, respectively, in ratios depending upon the nature of the ligand (dihydroquinine and dihydroquinidine 4-chlorobenzoates), the mode of hydroxyl groups protection and the pattern of double bond substitution.