A facile synthesis of optically active C2-symmetric 2,5-disubstituted pyrrolidines and other β,β′-dihydroxyamines

Article abstract of DOI:10.1016/0040-4039(94)85057-7

2,5-Dibromoadipic acid has been converted into the di-(R)-pantolactone ester of (S,S)-pyyrolidine-2,5-dicarboxylic acid in two steps. This compound serves as a precursor to C₂-symmetric 2,5-disubstituted pyrrolidines. The synthesis of linear C<