Introduction of carbogenic substituent into the 4-position of 1-methyl-1H-imidazole

DOI: 10.1248/cpb.42.821

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 821 - 825 (1994)

Update date:2022-08-03

Topics:

Authors:

Ohta Ohta

Yamamoto

Kawasaki

Yamashita

Nagashima

Yoshikawa

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Article abstract of DOI:10.1248/cpb.42.821

The 4-position of the 1-methyl-1H-imidazole ring was lithiated by treatment of the corresponding 4-bromo derivatives with tert-butyllithium. This procedure was applied to synthesis of the left-hand part of pyronaamidine (1), which is a biologically intere

Full text of DOI:10.1248/cpb.42.821

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