Chemical and Pharmaceutical Bulletin p. 821 - 825 (1994)
Update date:2022-08-03
Topics:
Ohta
Yamamoto
Kawasaki
Yamashita
Nagashima
Yoshikawa
The 4-position of the 1-methyl-1H-imidazole ring was lithiated by treatment of the corresponding 4-bromo derivatives with tert-butyllithium. This procedure was applied to synthesis of the left-hand part of pyronaamidine (1), which is a biologically intere
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