Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

DOI: 10.1021/acsmedchemlett.7b00418

Source and publish data:

ACS Medicinal Chemistry Letters p. 94 - 97 (2018)

Update date:2022-08-04

Topics:

Authors:

Shi, Weihua

Jiang, Zhigan

He, Haiying

Xiao, Fubiao

Lin, Fusen

Sun, Ya Sun, Ya

Hou, Lijuan

Shen, Liang

Han, Lixia

Zeng, Minggao

Lai, Kunmin

Gu, Zhengxian

Chen, Xinsheng

Zhao, Tao

Guo, Li Guo, Li

Yang, Chun

Li, Jian

Chen, Shuhui

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Article abstract of DOI:10.1021/acsmedchemlett.7b00418

A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e

Full text of DOI:10.1021/acsmedchemlett.7b00418

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Product name:tert-butyl 3-((2-bromophenyl)carbamoyl)azetidine-1-carboxylate

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