Novel Synthesis of a Mixed Phosphonic Anhydride. A route to Carboxylic Acid Derivatives from a Methyl Ketone

Article abstract of DOI:10.1016/0040-4039(94)88527-3

Conversion of a methyl ketone to the kinetic enol phosphate followed by ozonolysis provides a novel synthesis of a mixed phosphonic anhydride.This can either be isolated, or reacted in situ with nucleophiles to afford the corresponding acid derivatives.