A synthesis of Jaspamide based on 1,2-metallate rearrangements of α-heteroalkenylmetal derivatives

Article abstract of DOI:10.1055/s-1995-3870

Jaspamide (Jasplakinolide), a marine cyclodepsipeptide, was synthesised from tripeptide fragment 4 and (2S,4E,6R,8S)-8-benzoyloxy-2,4,6-trimethylnon-4-enoic acid (3). The tripeptide fragment was prepared from β-tyrosine derivative 6, Boc-2-bromoabrine (8)