An enantiospecific synthesis of β-amino acids

Article abstract of DOI:10.1016/S0040-4039(00)77503-4

L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee > 99%).