Novel and highly selective postsynaptic α-adrenoreceptor antagonists: Synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones

Article abstract of DOI:10.1016/0223-5234(96)88211-0

The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported. The blocking activity of these compounds was deterrnined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.