Total Synhesis of Balanol, Part 1. Enantioselective Synthesis of the Hexahydroazepine Ring via Chiral Epoxides and Azidirines

Article abstract of DOI:10.1016/0040-4020(95)00264-9

Three differents routes to the hexahydroazepine unit of the natural products balanol (1) and ophicordin (2) are described.The common starting material is the chiral epoxy alcohol 3 which is converted to the balanol degradation product 10 (Scheme 1) or to