Journal of the American Chemical Society p. 5938 - 5943 (1995)
Update date:2022-08-05
Topics:
Bulychev, Alexey
O'Brien, Michael E.
Massova, Irina
Teng, Min
Gibson, Tracy A.
Miller, Marvin J.
Mobashery, Shahriar
A novel class of N-sulfonyloxy β-lactam molecules are described as potent mechanism-based inactivators for the bacterial TEM-1 β-lactamase, a prototypic class A enzyme. These molecules inactivate the enzyme with k(inact)/K(i) values in the range of 1-7 x
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Doi:10.1016/0022-328X(95)05509-N
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