Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure

DOI: 10.1021/jm00022a011

Source and publish data:

Journal of Medicinal Chemistry p. 4463 - 4473 (1995)

Update date:2022-08-05

Topics:

Authors:

Romines Romines

Watenpaugh

Howe Howe

Tomich Tomich

Lovasz Lovasz

Morris Morris

Janakiraman

Lynn Lynn

Horng Horng

Chong Chong

Hinshaw Hinshaw

Dolak Dolak

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Article abstract of DOI:10.1021/jm00022a011

Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivat

Full text of DOI:10.1021/jm00022a011

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Product name:Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester

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