Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure

Article abstract of DOI:10.1021/jm00022a011

Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivat