Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure

DOI: 10.1021/jm00022a011

Source and publish data:

Journal of Medicinal Chemistry p. 4463 - 4473 (1995)

Update date:2022-08-05

Topics:

Authors:

Romines Romines

Watenpaugh

Howe Howe

Tomich Tomich

Lovasz Lovasz

Morris Morris

Janakiraman

Lynn Lynn

Horng Horng

Chong Chong

Hinshaw Hinshaw

Dolak Dolak

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00022a011

Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivat

Full text of DOI:10.1021/jm00022a011

Products guided by the article

Product name:Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester

Cas No:166282-28-6

R&D Labs maybe for 166282-28-6

Hangzhou Hysen Pharma co.,Ltd.

website:http://www.hysenpharma.cn/

Contact:0086-571-88298791

Address:#701,Gudun Road Hangzhou
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
XZL BIO-TECHNOLOGY CO., LTD.

Contact:0086 533 2282832

Address:Zibo，Shandong
Winchem Industrial Co. Ltd.(expird)

Contact:86-574-83851061 86-574-87083208

Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Jiangxi Province Bethel Pharmaceutical Co., Ltd.

Contact:+86-795-259 3456 ，+86-15957688008 13566650571

Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province

Relevant to this article

Migratory aptitude of the Zr-C functionalities bonded to a macrocyclic structure: Thermally- and solvent-assisted intra- and intermolecular migrations in dialkyl(dibenzotetramethyltetraazaannulene)zirconium(IV)

Doi:10.1021/ja00126a019
(1995)
Reactions of 2-butyne with group 6-group 10 heterobimetallics. New mixed-metal metallacycle chemistry

Doi:10.1021/om00006a044
(1995)
Syntheses of isotopically labeled 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro- 2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective ligand

Doi:10.1002/jlcr.2580360712
(1995)
Application of highly stereocontrolled glycosidations employing 2,6-anhydro-2-thio sugars to the syntheses of erythromycin A and olivomycin A trisaccharide

Doi:10.1021/ja00118a008
(1995)
Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels - Alder reactions

Doi:10.1021/ja982078+
(1999)
Rhodium(II) Acetate-catalysed Decomposition of 2-Diazo-3-oxobutanamides Derived from L-Phenylalanine

Doi:10.1002/prac.19953370160
(1995)

Article Doi