Bioorganic and Medicinal Chemistry Letters p. 403 - 406 (2000)
Update date:2022-08-03
Topics:
Keeling, Suzanne E.
Albinson, F. David
Ayres, Barry E.
Butchers, Peter R.
Chambers, C. Lynn
Cherry, Peter C.
Ellis, Frank
Ewan, George B.
Gregson, Michael
Knight, John
Mills, Keith
Ravenscroft, Paul
Reynolds, Linda H.
Sanjar, Shahin
Sheehan, Michael J.
A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A(2a) and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A(2a) receptor on the human neutrophil. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.
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